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Clinical Trials Search at Vanderbilt-Ingram Cancer Center



Study of the Safety, Tolerability and Efficacy of KPT-8602 in Participants With Relapsed/Refractory Cancer Indications

Multiple Myeloma

This is a first-in-human, multi-center, open-label clinical study with separate dose
escalation (Phase 1) and expansion (Phase 2) stages to assess preliminary safety,
tolerability, and efficacy of the second generation oral XPO1 inhibitor KPT-8602 in
participants with relapsed/refractory multiple myeloma (MM), metastatic colorectal cancer
(mCRC), metastatic castration resistant prostate cancer (mCRPC), higher risk myelodysplastic
syndrome (HRMDS), acute myeloid leukemia (AML) and newly diagnosed intermediate/high-risk
MDS.

Dose escalation and dose expansion may be included for all parts of the study as determined
by ongoing study results.
Multiple Myeloma
I/II
Mohan, Sanjay
NCT02649790
VICCHEM15112

Inotuzumab Ozogamicin with Standard Chemotherapy Regimen for the Treatment of Relapsed or Refractory B-cell Acute Lymphoblastic Leukemia

Multiple Cancer Types

This phase I trial studies the side effects and best dose of inotuzumab ozogamicin when given with 3 and 4 drug standard chemotherapy regimen in treating patients with B-cell acute lymphoblastic leukemia that has come back (relapsed) or does not respond to treatment (refractory). Inotuzumab ozogamicin is a monoclonal antibody, called inotuzumab, linked to a toxic agent called ozogamicin. Inotuzumab attaches to CD22 positive cancer cells in a targeted way and delivers ozogamicin to kill them. Chemotherapy drugs, such as daunorubicin, vincristine, cytarabine, methotrexate, and pegaspargase, work in different ways to stop the growth of cancer cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Anti-inflammatory drugs, such as prednisone lower the bodys immune response and are used with other drugs in the treatment of some types of cancer. Giving inotuzumab ozogamicin with standard chemotherapy may work better in treating patients with B-cell acute lymphoblastic leukemia compared to inotuzumab ozogamicin alone.
Leukemia, Phase I
I
Oluwole, Olalekan
NCT03962465
VICCHEMP20108

Treatment Response and Biomarker-Guided Steroid Taper for Children with GVHD

Multiple Cancer Types

This phase II trial studies the treatment response for patients with acute graft-versus-host disease (GVHD). GVHD occurs when donor immune cells attack the healthy tissue of a bone marrow or stem cell transplant patient. The standard treatment for GVHD is to lower the activity of the donor cells by using steroid medications such as prednisone. But steroid treatment may cause many complications and the risk of these complications increases with higher doses of steroids and longer treatment. It is important to find ways to decrease the steroid treatment in patients who do not need long courses. Researchers are doing this study to find out how many subjects respond well to lower steroid dosing based on a blood test (GVHD biomarker) and if they develop fewer complications.
Miscellaneous, Pediatrics
II
Kitko, Carrie
NCT05090384
VICCPED2213

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