Skip to main content

Clinical Trials Search at Vanderbilt-Ingram Cancer Center


Ball - Ambassadors

Sydney Ball
Sydney Ball

I joined the Vanderbilt-Ingram Cancer Center Ambassadors in 2017 through the Young Leaders Council Leadership Program. The VICC Ambassadors are an amazing group of passionate individuals that I am thankful to have the opportunity to partner alongside in the fight against cancer. Our experience together has been incredible; the influence we have made has been significant; and the friendships we have formed have been endearing.

I think everyone has been impacted, at some level, by cancer. However, cancer had a dramatic impact on my life in 2016 when my grandfather lost his fight to lung cancer and my cousin died of an undiagnosed metastatic cancer. Being able to raise awareness about cancer research through the VICC Ambassadors has been a meaningful way for me to give back to the community, while also awarding discovery grants for a cause that has closely impacted my family.

As part of the VICC Ambassadors, you will have the opportunity to be educated on trends in medical research, vote on where the research dollars are distributed, and help raise awareness for innovative philanthropic efforts. We look forward to you partnering with us on this journey and hope you will participate in any way that you can!


SMART Precision Cancer Medicine

A diagnosis of cancer is a life-changing event whi


Writing series offered for people affected by cancer

The Express Yourself Fall Creative Writing Series begins Oct. 24 for cancer patients and others who have been affected by cancer.

Hertha - Ambassadors

Erin Hertha
Erin Hertha

The mission to find a cure for cancer is something I strongly believe in and value. Most of us have our own stories about how cancer has affected someone we loved dearly. My story is about my mother, who was diagnosed with lung cancer in 2001. At the time, we lived in a small city where there was not a powerful resource like Vanderbilt-Ingram Cancer Center. The doctors tried to do what they could, but her advanced cancer was past the point of intervention. My mother lost her battle on November 10, 2001, two months after my 13th birthday. Cancer left a void in my heart by taking one of the people I loved most in the world.  

Eighteen years later, my path led me to Vanderbilt-Ingram Cancer Center where I work under the incredible leadership of Jennifer Pietenpol, PhD. The work, passion and devotion I witness daily from Dr. Pietenpol, leadership and staff in Vanderbilt-Ingram show me why we are the leader in prevention, diagnosis and treatment of cancer. 

I joined VICC Ambassadors because of my passion for finding cures and my belief in this program. My story may not have had the ending I hoped for, but I am optimistic that the VICC Ambassadors can help make great strides toward giving others better endings to their stories.
 


An Open-Label, Dose-Escalation / Dose-Expansion Safety Study of INCB059872 in Subjects With Advanced Malignancies

Multiple Cancer Types

This is an open-label, dose-escalation / dose-expansion study of INCB059872 in subjects with advanced malignancies. The study will be conducted in 4 parts. Part 1 (mono therapy dose escalation) will determine the recommended dose(s) of INCB059872 for dose expansion, based on maximum tolerated dose and / or a tolerated pharmacologically active dose. Part 2 (dose expansion) will further determine the safety, tolerability, efficacy, PK, and PD of the selected monotherapy dose(s) in AML / MDS, SCLC, myelofibrosis, Ewing sarcoma, and poorly differentiated neuroendocrine tumors. Part 3 will determine the recommended dose(s) of INCB059872 in combination with azacitadine and all-trans retinoic acid in AML and in combination with nivolumab in SCLC. Part 4 will further determine the safety, tolerability, efficacy, PK, and PD of the selected combination dose(s) in Part 3.
Hematologic, Leukemia, Lung, Miscellaneous, Small Cell
I/II
Savona, Michael
NCT02712905
VICCHEMP1615

Fulvestrant or Exemestane with or without Ribociclib in Patients with Recurrent, Unresectable, or Metastatic Hormone Receptor Positive, HER2 Negative Breast Cancer

Breast

This randomized, phase II trial studies how well fulvestrant or exemestane with or without ribociclib works in treating patients with hormone receptor positive, human epidermal growth factor receptor 2 (HER2) negative breast cancer that has progressed after treatment with an aromatase inhibitor or cyclin-dependent kinase 4 / 6 inhibitor, cannot be removed by surgery, or has spread to other parts of the body. Hormone therapy using fulvestrant or exemestane may fight breast cancer by blocking the use of estrogen by the tumor cells or reducing the amount of estrogen made by the body. Ribociclib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Giving fulvestrant or exemestane with ribociclib may be an effective treatment for patients with breast cancer.
Breast
II
Mayer, Ingrid
NCT02632045
VICCBRE15147

Study of INCB053914 in Subjects With Advanced Malignancies

This is an open-label, dose-escalation study of the proviral integration site of Moloney murine leukemia virus (PIM) kinase inhibitor INCB053914 in subjects with advanced malignancies. The study will be conducted in 4 parts. Part 1 (monotherapy dose escalation) will evaluate safety and determine the maximum tolerated dose of INCB053914 monotherapy and the recommended phase 2 dose(s) (a tolerated pharmacologically active dose that will be taken forward into the remaining parts of the study). Part 2 (monotherapy dose expansion) will further evaluate the safety, efficacy, pharmacokinetics (PK), and pharmacodynamics (PD) of the recommended Phase 2 dose(s). Part 3 (combination dose finding) will evaluate safety of INCB053914 in combination with select standard of care (SOC) agents and will identify the optimal INCB053914 dose in combination with conventional SOC regimens to take forward into Part 4. Part 4 (combination dose expansion) will further evaluate the safety, efficacy and pharmacokinetics of the recommended Phase 2 dose combination(s).
Not Available
I/II
Savona, Michael
NCT02587598
VICCHEM1592

Palbociclib in Combination with Fulvestrant or Tamoxifen Citrate in Treating Patients with Locally Advanced or Metastatic Hormone Receptor Positive Breast Cancer

This phase II trial studies the side effects of palbociclib when given together with fulvestrant or tamoxifen citrate in treating patients with hormone receptor positive breast cancer that has spread from where it started to nearby tissue or lymph nodes (locally advanced) or has spread to other places in the body (metastatic). Palbociclib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Hormone therapy using fulvestrant or tamoxifen citrate may fight breast cancer by blocking the use of estrogen by the tumor cells. Giving palbociclib together with fulvestrant or tamoxifen citrate may work better in treating hormone receptor positive breast cancer.
Not Available
II
Mayer, Ingrid
NCT02384239
VICCBRE15120

Cisplatin, Romidepsin and Nivolumab in Treating Patients with Locally Recurrent or Metastatic Triple Negative Breast Cancer

Breast

This phase I / II trial studies the side effects and best dose of romidepsin when given together with cisplatin and nivolumab, to see how well they work in treating patients with triple negative breast cancer that has come back at or near the same place as the original (primary) tumor, usually after a period of time during which the cancer could not be detected or spread to other parts of the body. Romidepsin may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Drugs used in chemotherapy, such as cisplatin, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Romidepsin may also help cisplatin work better. Monoclonal antibodies, such as nivolumab, may interfere with the ability of tumor cells to grow and spread. Giving romidepsin together with cisplatin and nivolumab may be a better treatment for tripe negative breast cancer.
Breast
I/II
Abramson, Vandana
NCT02393794
VICCBRE1674

eXalt3: Study Comparing X-396 (Ensartinib) to Crizotinib in ALK Positive Non-Small Cell Lung Cancer (NSCLC) Patients

Lung

The primary purpose of this study is to evaluate the efficacy and safety of X-396 (ensartinib) vs. crizotinib in patients with ALK-positive non-small cell lung cancer that have received up to 1 prior chemotherapy regimen and no prior ALK inhibitor.
Lung
III
Horn, Leora
NCT02767804
VICCTHO15129

To learn more about any of our clinical
trials, call 1-800-811-8480 or complete
the online Self-Referral Form here: