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Clinical Trials Search at Vanderbilt-Ingram Cancer Center


Ball - Ambassadors

Sydney Ball
Sydney Ball

I joined the Vanderbilt-Ingram Cancer Center Ambassadors in 2017 through the Young Leaders Council Leadership Program. The VICC Ambassadors are an amazing group of passionate individuals that I am thankful to have the opportunity to partner alongside in the fight against cancer. Our experience together has been incredible; the influence we have made has been significant; and the friendships we have formed have been endearing.

I think everyone has been impacted, at some level, by cancer. However, cancer had a dramatic impact on my life in 2016 when my grandfather lost his fight to lung cancer and my cousin died of an undiagnosed metastatic cancer. Being able to raise awareness about cancer research through the VICC Ambassadors has been a meaningful way for me to give back to the community, while also awarding discovery grants for a cause that has closely impacted my family.

As part of the VICC Ambassadors, you will have the opportunity to be educated on trends in medical research, vote on where the research dollars are distributed, and help raise awareness for innovative philanthropic efforts. We look forward to you partnering with us on this journey and hope you will participate in any way that you can!


SMART Precision Cancer Medicine

A diagnosis of cancer is a life-changing event whi

Hertha - Ambassadors

Erin Hertha
Erin Hertha

The mission to find a cure for cancer is something I strongly believe in and value. Most of us have our own stories about how cancer has affected someone we loved dearly. My story is about my mother, who was diagnosed with lung cancer in 2001. At the time, we lived in a small city where there was not a powerful resource like Vanderbilt-Ingram Cancer Center. The doctors tried to do what they could, but her advanced cancer was past the point of intervention. My mother lost her battle on November 10, 2001, two months after my 13th birthday. Cancer left a void in my heart by taking one of the people I loved most in the world.  

Eighteen years later, my path led me to Vanderbilt-Ingram Cancer Center where I work under the incredible leadership of Jennifer Pietenpol, PhD. The work, passion and devotion I witness daily from Dr. Pietenpol, leadership and staff in Vanderbilt-Ingram show me why we are the leader in prevention, diagnosis and treatment of cancer. 

I joined VICC Ambassadors because of my passion for finding cures and my belief in this program. My story may not have had the ending I hoped for, but I am optimistic that the VICC Ambassadors can help make great strides toward giving others better endings to their stories.
 


Radiation Therapy with or without Apalutamide in Treating Patients with Stage III-IV Prostate Cancer

This phase II trial studies how well radiation therapy with or without apalutamide works in treating patients with stage III-IV prostate cancer. Radiation therapy uses high energy x-ray to kill tumor cells and shrink tumors. Androgen can cause the growth of prostate cancer cells. Drugs, such as apalutamide, may lessen the amount of androgen made by the body. Giving radiation therapy and apalutamide may work better at treating prostate cancer.
Not Available
II
Kirschner, Austin
NCT03371719
NRGUROGU006

A Study of GDC-9545 Alone or in Combination With Palbociclib and / or Luteinizing Hormone-Releasing Hormone (LHRH) Agonist in Locally Advanced or Metastatic Estrogen Receptor-Positive Breast Cancer

Breast

This study will evaluate the safety, pharmacokinetic (PK), pharmacodynamic (PD) activity, and preliminary anti-tumor activity of GDC-9545 as a single agent and in combination with palbociclib and / or luteinizing hormone?releasing hormone (LHRH) agonist in patients with advanced or metastatic estrogen receptor (ER)-positive (human epidermal growth factor receptor 2 [HER2]-negative) breast cancer.
Breast
I
Mayer, Ingrid
NCT03332797
VICCBREP1786

My Pathway: A Study Evaluating Herceptin / Perjeta, Tarceva, Zelboraf / Cotellic, Erivedge, Alecensa, and Tecentriq Treatment Targeted Against Certain Molecular Alterations in Participants With Advanced Solid Tumors

Miscellaneous

This multicenter, non-randomized, open-label study will evaluate the efficacy and safety of six treatment regimens in participants with advanced solid tumors for whom therapies that will convey clinical benefit are not available and / or are not suitable options per the treating physician's judgment.
Miscellaneous
II
Davis, Elizabeth
NCT02091141
VICCMD16103

Adavosertib in Treating Patients with SETD2-Deficient Locally Advanced or Metastatic Solid Tumors

This phase II trial studies how well adavosertib works in treating patients with SETD2-deficient solid tumors that have spread to other places in the body. Adavosertib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth.
Not Available
II
Rathmell, Kim
NCT03284385
VICCURO18153

Open-label Study of FT-2102 With or Without Azacitidine or Cytarabine in Patients With AML or MDS With an IDH1 Mutation

Multiple Cancer Types

This Phase 1 / 2 study will evaluate the safety, efficacy, PK, and PD of FT-2102 as a single agent or in combination with azacitidine or cytarabine. The Phase 1 stage of the study is split into 2 distinct parts: a dose escalation part, which will utilize an open-label design of FT-2102 (single agent) and FT-2102 + azacitidine (combination agent) administered via one or more intermittent dosing schedules followed by a dose expansion part. The dose expansion part will enroll patients in up to 5 expansion cohorts, exploring single-agent FT-2102 activity as well as combination activity with azacitidine or cytarabine. Following the completion of the relevant Phase 1 cohorts, Phase 2 will begin enrollment. Patients will be enrolled across 6 different cohorts, examining the effect of FT-2102 (as a single agent) and FT-2102 + azacitidine (combination) on various AML / MDS disease states.
Leukemia, Myelodysplastic Syndrome
I/II
Ferrell, Paul
NCT02719574
VICCHEM1709

A Study Evaluating KTE-X19 in Adult Subjects With Relapsed / Refractory B-precursor Acute Lymphoblastic Leukemia (ZUMA-3)

The primary objectives of this study are to determine the safety and efficacy of KTE-X19 adult participants with relapsed / refractory (r / r) B-precursor acute lymphoblastic leukemia (ALL).
Not Available
I/II
Oluwole, Olalekan
NCT02614066
VICCBMT15150

Response and Biology-Based Risk Factor-Guided Therapy in Treating Younger Patients with Non-high Risk Neuroblastoma

Neuroblastoma (Pediatrics)

This phase III trial studies how well response and biology-based risk factor-guided therapy works in treating younger patients with non-high risk neuroblastoma. Sometimes a tumor may not need treatment until it progresses. In this case, observation may be sufficient. Measuring biomarkers in tumor cells may help plan when effective treatment is necessary and what the best treatment is. Response and biology-based risk factor-guided therapy may be effective in treating patients with non-high risk neuroblastoma and may help to avoid some of the risks and side effects related to standard treatment.
Neuroblastoma (Pediatrics)
III
Pastakia, Devang
NCT02176967
COGANBL1232

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