My research interests fall under the general theme of understanding the structural basis for recognition, biochemical function and biological specificity of proteins and nucleic acids. My background in chemistry frames the way I think, but the deciding factor for choosing problems is not the approach, but rather the biomedical problem. Another key characteristic is tight coupling of our research to functional analysis. This strategy is by nature very collaborative and collegial, and has stimulated involvement in several multi-investigator research programs.

Our structural biology research focuses on the cutting edge of the technology and its application to increasingly complex systems. A significant part of our research is now devoted to multi-protein complexes, with programs studying various aspects of genome maintenance ranging from DNA replication to damage response and repair.