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The Signal Transduction and Chemical Biology Research Program is organized into four groups with common research interests:

Identifying how changes in key cell cycle proteins help tumor cells escape the typical response of cell death and lead to uncontrollable growth

Finding and developing compounds that inhibit key drivers of cancer formation

Combining ‘big data’ experimental approaches to understand the changes in signaling networks that drive cancer formation

Determining how cancer-initiating stem cells continuously renew and seed distant sites to promote metastasis, and understanding the role of these cells in resistance to chemotherapies

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Signal Transduction and Chemical Biology Research Program

The pathways that send chemical signals from the cell surface to the nucleus are major targets of genotype-driven therapies for cancer. The Signal Transduction and Chemical Biology Research Program aims to better understand how changes in tumor cells alter these signaling networks, and to identify—or create—molecules that target these pathways as potential new therapies for cancer.

Meet the Program Members

The Signal Transduction and Chemical Biology program, led by Ian Macara, Ph.D., and Stephen Fesik, Ph.D., is an active group of more than 40 basic, translational, and clinical scientists whose goal is to understand how signaling networks control cell proliferation and function, to identify drug leads, and to develop new cancer therapeutics.

Featured Publications

Program News

February 4, 2021

Gene network for leukemia factor

Transcription factors — proteins that regulate gene expression — play critical roles in cell fate decisions and are frequent targets of mutation in a variety of human cancers.
January 25, 2021

An interacting factor in leukemia

TG-Interacting Factor 1 (TGIF1) is a protein that regulates self-renewal of hematopoietic stem cells, which give rise to other blood cells, and which affects proliferation and differentiation of myeloid cells.
September 6, 2019

The plus and minus of microtubules

Understanding the dynamic regulation of cytoskeletal microtubules may suggest new ways to treat disorders ranging from Alzheimer's disease to cancer.