A study led by researchers from Vanderbilt University Medical Center has discovered genetic susceptibilities that may shed light on why people of African ancestry are disproportionately affected by lung cancer.  

Prior research has shown that Americans of African ancestry have a higher risk of lung cancer compared to white Americans despite smoking fewer cigarettes, but the reasons for this difference are not fully understood, and studies that delve into genetic susceptibilities for lung cancer among this population group have been limited. New research published Aug. 18 in the American Journal of Human Genetics revealed a total of 10 genomic regions — four of which had never been previously reported — associated with lung cancer. 

The researchers performed genome-wide association studies on 6,490 people of African ancestry that included 2,390 with a diagnosis of lung cancer and a control group of 4,100 for comparison. 

The authors confirmed that a well-known genetic region on chromosome 15 plays a major role in lung cancer risk across populations. The authors also discovered four additional genetic regions (on chromosomes 3, 8, 14 and 18) that had not been linked to lung cancer before. When their findings were combined with results from European and Asian populations, a total of 17 genetic regions were associated with lung cancer risk. Several genes in these regions are involved in biological processes such as lung function, cell growth and DNA repair.  

“Our work provides a critical advance in lung cancer by improving our limited understanding of genetic susceptibility in African ancestry populations and offers insights that may guide future treatment efforts,” said the study’s corresponding author, Melinda Aldrich, PhD, MPH, professor of Medicine, Thoracic Surgery and Biomedical Informatics at Vanderbilt.  

Aldrich and Jacklyn Hellwege, PhD, research assistant professor of Medicine, are the study’s senior authors. 

“This work was uniquely positioned to make use of advances in statistical modeling and genetic ancestry information to ultimately make new insights into the genetic architecture of lung cancer in this at-risk population,” said Hellwege. 

VUMC researchers received support from National Institutes of Health grants (U01CA253560, U01CA202979, R01CA141769, R01ES006717, P30CA022453 and P30CA068485) for the study. 

Other VUMC authors on the study are Michael Betti, PhD, James Jaworski, MPH, Shilin Zhao, PhD, and Eric Gamazon, PhD, MS. 

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In a collaboration between Vanderbilt University Medical Center’s Department of Otolaryngology-Head and Neck Surgery and the Vanderbilt University School of Engineering, investigators have received a $2.5 million grant to develop a head-mounted augmented reality system that can guide surgeons in ensuring complete tumor removal in head and neck cancer surgery and potentially reduce the recurrence rate of tumors. 

The National Institutes of Health grant was awarded to primary investigator Jie Ying Wu, PhD, assistant professor of Computer Science, with secondary appointments in Biomedical Engineering, Electrical and Computer Engineering, and Mechanical Engineering at Vanderbilt University. Wu also has an appointment in the Department of Surgery at Vanderbilt University Medical Center. 

Co-investigators include Michael Miga, PhD, director of the Vanderbilt Institute for Surgery and Engineering and the Harvie Branscomb Professor and chair of the Department of Biomedical Engineering, as well as Michael Topf, MD, associate professor of Otolaryngology-Head and Neck Surgery, and Matthew Weinger, MD, professor of Anesthesiology and Biomedical Informatics. 

“I am delighted to receive this award to transform surgical care for head and neck cancer,” said Wu. “This funding will allow us to build novel deformation models for heterogeneous tissue shrinkage and ensure the augmented reality software design is intuitive for surgeons and fits within the clinical workflow.” 

The development of the technology stems from a deficit Topf noticed in surgical oncology. While three-dimensional scanning has become part of the norm for other aspects of patient care, from same-day dental crowns to prosthetic limbs, Topf was troubled by the lack of application for 3D scanning in oncologic surgery. Topf implemented a protocol to create 3D models of resected cancers for surgeons, pathologists and oncologists to reference. 

“We came up with a way to 3D scan a surgical specimen in real time in less than 10 minutes prior to processing and not interfere with all the other important things that are going on in the pathology lab,” said Topf. “Encouragingly, this is a widely transferable practice and would be applicable to most cancer surgeries, from orthopaedic oncology to breast cancer.” 

Weinger, who is a faculty member of the Center for Research and Innovation in Systems Safety (CRISS) at VUMC, expressed the organization’s eagerness to support the research. 

“CRISS is excited to contribute to this important project, applying advanced engineering to ensure the user interface of this technology guides surgeons to safely and effectively treat cancer patients,” said Weinger, who holds the Norman Ty Smith Chair in Patient Safety and Medical Simulation. 

Safety and effectiveness are at the core of the research. As Miga explained, the 3D mapping technology will allow surgeons to rely less on a fallible mental construction of the resection plane, thereby reducing the risk of human error affecting the procedure. 

“When it comes to cancer surgery, surgeons often say, ‘We think we got it all,’” said Miga. “What many don’t realize is that every operation requires the surgeon to construct a mental spatial map, linking the visible surgical field to their internal understanding of the tumor’s extent. It’s an incredibly complex task, and sometimes, despite best efforts, reoperations are necessary. 

“Now imagine if, while the patient is still on the table, we could detect the margin in real time, and then, using a holographic overlay, highlight the precise region that needs further attention. Through our collaboration, that’s the kind of transformation we’re seeking to make commonplace with this research.” 

Collaboration has been consistent over the last few years between the Medical Center and the University, said Wu. She hopes research into the technology will eventually support a clinical trial, a sentiment shared by Eben Rosenthal, MD, Barry and Amy Baker Professor and chair of the Department of Otolaryngology-Head and Neck Surgery. 

“Improving surgical outcomes is of the utmost importance, especially when it comes to ensuring total tumor removal and reduced risk of recurrence for cancer patients,” said Rosenthal. “The research supported by this grant will help us perfect this technology as we seek practical applications for patient care, including clinical trials and, eventually, everyday use in the operating room.” 

This study is supported by NIH grant R01EB037685. 

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Susan Morrow kept too busy to be bored, whether she was teaching deaf children to speak, starting new business ventures or confronting cancer.

Ovarian cancer crept into her life the way it most often does — unsuspected and without warning. The first symptom occurred in 2020 when she noticed herself gasping for breath during a trip to the North Carolina mountains and thought she might have COVID-19.

After receiving the cancer diagnosis, she met the challenges with heroic stamina and analytical reasoning. She sought emerging treatment options, volunteered to raise awareness about the disease, and chronicled her journey with meticulous emails.

Two years after her death, her story continues. The Susan Morrow Legacy Foundation has made a generous donation to support ovarian cancer research at Vanderbilt University and Vanderbilt University Medical Center.

“She was an incredibly driven, incredibly interesting person and the light of my life,” said her husband, Ron Morrow, who has filled the seat on the Vanderbilt-Ingram Cancer Center Board of Advisors that she once held.

Vanderbilt-Ingram was where she received her initial treatment and surgery. The gift in her honor will support studies that are evaluating new microbubble imaging strategies and other molecular studies being developed by Todd Giorgio, PhD, professor of Biomedical Engineering and of Chemical and Biomolecular Engineering, to detect the earliest cancer or precancer lesions within the fallopian tubes.

Morrow’s tenacity and energy left an impression with Ronald Alvarez, MD, MBA, chair and clinical service chief of Obstetrics and Gynecology. This support will continue her legacy and help other women facing this disease.

“Past attempts to develop effective ovarian cancer screening strategies have been unsuccessful. The research we have asked the Morrow Foundation to support will hopefully provide preliminary evidence in preclinical models that this novel imaging strategy may be an effective ovarian cancer screening approach,” said Alvarez, the Betty and Lonnie S. Burnett Professor of Obstetrics and Gynecology.

Ben Ho Park, MD, PhD, director of Vanderbilt-Ingram, said Susan Morrow was an engaged and energetic member of the Board of Advisors.

“Beyond this generous gift, Ron and Susan Morrow have both been valuable to our mission by volunteering to serve on our board,” said Park, the Benjamin F. Byrd Jr. Professor of Oncology and professor of Medicine. “We appreciate the leadership that Susan provided and the continuing commitment from Ron to advance cancer care and research.”

The daughter of a U.S. Army colonel, Susan Morrow spent her early years wherever her father was stationed, but she grew up in El Paso, Texas, following his retirement. After graduating from the University of Texas and then receiving a Master of Education from Harvard University, she taught speech to children with profound deafness, worked in the investment business and then transitioned into an entrepreneurial career, establishing an executive search firm as well as direct sales company for women’s clothing. When she moved to Park City, Utah, she met Ron Morrow, and the couple married in 2006.

He changed the name of the family’s charitable foundation to honor her following her death on Sept. 28, 2022.

“Medical issues became extremely important, and we made ovarian cancer a focus because often a woman doesn’t know she has it until it’s Stage 3 or maybe Stage 4,” Morrow said. “That was certainly the case with Susan. She had no cancer in her family at all, ever.”

Awareness about ovarian cancer and improving early detection is a focus for the foundation, which will host the Susan Morrow Drive to Survive Golf Tournament at the Old Tabby Links course in Spring Island, South Carolina, on Oct. 6.

Morrow said she left him a gift of peace that he and his family would like to keep giving.

“When we were married, I didn’t think she was an extremely religious person,” he said. “She obviously believed in God, but we didn’t go to church every week. It was something that was in our life, but it didn’t encompass us. As she was dying, she had read a book called ‘Proof of Life.’ And as she was dying, I was holding her, and she looked off into the distance and looked up, then looked over to me and said, ‘It’ll be OK.”

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Stand Up to Cancer, a one-hour, commercial-free special promoting the life-saving advances of cancer research, and to raise funds for new treatments and cures, was broadcast Friday Aug. 15 on more than 30 participating media platforms, including national TV networks ABC, NBC, CBS and FOX.

Viewers saw performances by host Sheryl Crow, as well as the Jonas Brothers, Noah Cyrus, Gavin DeGraw, Marcus King, Brothers Osborne, Jon Pardi, Jelly Roll, Dan + Shay and CeCe Winans (joined by Nashville Community Gospel Choir).

During the telecast, Vanderbilt-Ingram Cancer Center (VICC) was highlighted and mentioned several times. During a segment on the role of artificial intelligence in cancer diagnosis and treatment, Ben Ho Park, MD, PhD, director of VICC, and Tae Hyun Hwang, PhD, professor of Surgery, both were among those featured. In addition, Brothers Osborne asked everyone from VICC who was in attendance to stand up for a round of applause, and, in a taped segment, Keith Urban mentioned VICC and Vanderbilt Health.

The full telecast is now available for viewing on YouTube at this link:

The one-hour broadcast special was taped at The Pinnacle in downtown Nashville on Aug. 9. Before taping the show, a pre-taping party was attended by approximately 1,000 VUMC and Vanderbilt-Ingram Cancer Center physicians, nurses and staff and their guests. Pictures from that event are here.

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Stand Up to Cancer, a one-hour, commercial-free special promoting the life-saving advances of cancer research, and to raise funds for new treatments and cures, will air simultaneously on Friday night, Aug. 15, at 7 p.m., CDT on over 30 participating media platforms, including national TV networks ABC, NBC, CBS and FOX.

The one-hour broadcast special was taped at The Pinnacle in downtown Nashville on Aug. 9. Before taping the broadcast, a pre-taping party was attended by approximately 1,000 VUMC and Vanderbilt-Ingram Cancer Center physicians, nurses and staff and their guests.

All four major U.S. broadcast networks will carry the show, with broadcasters donating prime time slots to support the cause. The telecast will also be available to watch on-demand across multiple digital and streaming platforms, ensuring broad and flexible access to this one-night-only event.

Those who made their way inside for the taping saw performances by the Jonas Brothers, Noah Cyrus, Gavin DeGraw, Marcus King, Brothers Osborne, Jon Pardi, Jelly Roll, Dan + Shay and CeCe Winans (joined by Nashville Community Gospel Choir), as well as the host for the event, Sheryl Crow.

For more details about the show and about Stand Up to Cancer, go here.

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Kaille Meguiar, DO, MPH, an oncologist in the Division of Pediatric Hematology/Oncology at Monroe Carell Jr. Children’s Hospital at Vanderbilt, has been awarded a $100,000 Hyundai Hope on Wheels Impact Award to research the psychosocial and neurocognitive outcomes of survivors of pediatric, adolescent and young adult cancers.

Hyundai Hope on Wheels, which includes funding from Hyundai Motor America and local dealerships, has awarded more than $2 million in funding to pediatric cancer researchers at Monroe Carell since 2007.

Every year, more than 15,000 children are diagnosed with cancer. Thanks to advancements in treatments, approximately 85% of these children now survive five years or longer. However, there is an increasing need to address the long-term challenges survivors face beyond physical health, including higher rates of anxiety and depression; impaired task efficiency and memory; and long-term problems with attention and executive functions.

With the latest grant award to Monroe Carell, Meguiar’s work will focus on understanding how cancer and its treatment impact survivors’ mental and cognitive well-being, as well as how to better support them and their caregivers.

After completing her DO degree and internal medicine and pediatric residencies at Corewell Health/Helen DeVos Children’s Hospital, Meguiar joined Monroe Carell as a Division of Pediatric Hematology/Oncology fellow. During her fellowship, she developed a research project to identify the risk factors for negative psychosocial outcomes in childhood cancer survivors. Her work earned a National Institutes of Health training grant. With the support of the Hyundai Impact Award, she will expand her research by creating a cohort to study neurocognitive outcomes and develop interventions to improve survivors’ quality of life.

“I am honored to receive this award, which will allow me to continue my work focused on improving the lives of childhood cancer survivors and their families,” said Meguiar, who joined the Vanderbilt faculty in July 2025. “I look forward to advancing our understanding of these challenges and finding ways to make a meaningful difference. Thank you to Hyundai and the local dealerships for supporting this important work to enhance the comprehensive long-term care for childhood cancer survivors.”

Representatives from Hyundai and local dealerships presented a check and an honorary lab coat to Meguiar during a special celebration at Monroe Carell. The event also included patient Greta Ford, 4, and her dad, Adam, and mom, Rachel Modhal, who shared their daughter’s cancer journey with leukemia and described Meguiar as their “rock” through it all.

The event was followed by a “handprint” ceremony where cancer patients dipped their hands in paint and put their handprints on a white Hyundai Palisade, with each handprint representing their personal stories of hope and courage.

“This is about the families who inspire us every day — and the scientific pioneers, like those here today, who are leading innovative and lifesaving research,” said Scott Harrison, senior sales manager for Hyundai Motor America Southern region. “Their breakthroughs are pushing the boundaries of medicine and providing kids with treatments that were unthinkable five or 10 years ago. Because of this, more children are surviving this disease. More kids can play sports, make friends, graduate from high school, build a life for themselves and find their place in the world. More kids have a second chance at life. This is the beating heart of everything we do.”

In celebration of Hope on Wheels’ 27th anniversary, Hyundai will award $27 million in grants to institutions across the country, including Monroe Carell. HHOW has donated more than $277 million in grants since its inception in 1998.

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A two-drug combination for treating advanced kidney cancer had sustained and durable clinical benefit in more than five years of follow-up, according to a study published Aug. 1 in Nature Medicine. 

The study reports final clinical data and biomarker analyses from the Phase 3 KEYNOTE-426 trial, which compared the drug combination pembrolizumab plus axitinib versus the single drug sunitinib for patients with previously untreated advanced clear cell renal cell carcinoma, the most common type of kidney cancer.

“KEYNOTE-426 was the first trial to combine a PD-1 inhibitor immunotherapy (pembrolizumab) with a VEGF receptor inhibitor antiangiogenic drug (axitinib) in the first-line setting for advanced renal cell carcinoma. It therefore has the longest follow-up duration among the various trials comparing these types of drug combinations,” said Brian Rini, MD, a medical oncologist at Vanderbilt-Ingram Cancer Center and the study’s lead and corresponding author. 

Immunotherapy drugs like pembrolizumab stimulate the immune system to kill tumor cells. VEGF receptor inhibitors like axitinib and sunitinib block angiogenesis — the development of blood vessels that tumors need to grow and spread. Pembrolizumab plus axitinib and other immunotherapy-antiangiogenic drug combinations are now standard first-line treatments for advanced kidney cancer. 

“Before the development of antiangiogenic drugs and immunotherapies, advanced renal cell carcinoma had a very poor prognosis. These drug combinations have dramatically improved treatment options and outcomes for patients,” said Rini, Thomas F. Frist Sr. Professor of Medicine. 

The first interim analysis of outcomes from KEYNOTE-426, published Feb. 16, 2019, in the New England Journal of Medicine, demonstrated that trial participants treated with pembrolizumab plus axitinib had longer overall and progression-free survival, and higher objective response rates compared to those taking sunitinib. The median follow-up was 12.8 months. 

Now, with a median follow-up of 67.2 months, the current analysis confirms and extends the interim analysis and provides valuable information about biomarkers that could help guide treatment decisions. 

The study in Nature Medicine reports that pembrolizumab plus axitinib had longer overall survival (47.2 months versus 40.8 months for sunitinib) and longer progression-free survival (15.7 months versus 11.1 months for sunitinib). The objective response rate was 60.6% for pembrolizumab plus axitinib and 39.6% for sunitinib. 

The researchers reported a variety of associations between the expression of biomarkers and outcomes (overall survival, progression-free survival, objective response rate). The biomarkers they evaluated included an 18-gene T-cell-inflamed expression profile, angiogenesis signature, and PD-1 ligand expression. 

“There is an unmet need for biomarkers that are predictive of patient outcomes following treatment with available first-line therapies for advanced renal cell carcinoma,” Rini said. “Although our analysis showed potential clinical utility of some RNA signatures in identifying patients who are likely to benefit the most from each treatment, further prospective clinical studies are needed.” 

Pembrolizumab plus axitinib is a first-line treatment option for patients with advanced renal cell carcinoma regardless of biomarker subtypes, he noted. 

The research was supported by the pharmaceutical company Merck Sharp & Dohme LLC, which played a role in the study design and conduct.

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The first class has completed the VERTICAL Program at Vanderbilt-Ingram Cancer Center, which provides medical and graduate school preparation for aspiring oncologists and cancer researchers.

The program was established in 2023 with financial support from the American Cancer Society, and Vanderbilt-Ingram had an inaugural class of four fellows. This was followed by the enrollment of another fellow in 2024.

“This is a two-year program that gives trainees a robust mentored research experience,” said Kimberly Dahlman, PhD, associate professor of Medicine, who is the assistant director of Research Education at Vanderbilt-Ingram. “In addition to being embedded in a cancer research laboratory, fellows also participate in professional development and cancer education activities, including career-path, lunch-and-learn sessions and cancer biology coursework.

“They are also involved in community service projects related to cancer. This program gives them dedicated time to prepare for their medical school or graduate school applications, in addition to their research experiences.”

In August, another class of four fellows will start the VERTICAL Program, which is kept small so it can be tailored to individual development plans. The participants do not receive credits toward graduate degrees, but they do become more competitive for acceptance into medical and graduate school programs.

“The VERTICAL Program gave me the final push I needed to pursue a PhD,” said Asia Miller, a member of the inaugural class from Indiana, who has a bachelor’s degree from Vanderbilt University in Biological Sciences “I was not confident in my identity as a researcher before the program, despite having done research in all four years of college. This was the best professional and personal development experience I have ever had.”

Bryan Hernandez, another inaugural class member who has a bachelor’s degree in Neuroscience from The University of Texas at El Paso, said he is looking forward to a career as a physician-scientist.

“The VERTICAL Program provided me with the perfect combination of structured mentoring and independent guidance throughout my two years in the program,” Hernandez said. “This dynamic exposed me to more robust career-building opportunities in areas of cancer research and medicine I was not previously familiar with. Thanks to my time in the VERTICAL Program, I was able to progress into the next formative step in my intended career path as a physician-scientist with a newfound outlook on the field of science and medicine I had been interested in.”

VERTICAL is an acronym for Vanderbilt Education Research and Training in Cancer and Leadership Program. It is open to individuals with bachelor’s degrees from nationally accredited colleges or universities who desire to pursue doctoral degrees and careers in science or medicine with a focus on cancer. Participants are paid a living wage.

“We also pay for MCAT preparation for fellows who want to take the MCAT for medical school applications,” said Dahlman, who is also co-director of the third- and fourth-year undergraduate medical education curriculum at Vanderbilt University School of Medicine.

VERTICAL fellows at Vanderbilt-Ingram are also offered the opportunity to do clinical shadowing and are provided financial support to attend one conference a year to present their research.

Vanderbilt-Ingram was selected as one of the five initial pilot locations for the postbaccalaureate fellows program, which was started by the American Cancer Society. Each of the pilot institutions has its own name for the program. Debra Friedman, MD, MS, holder of the E. Bronson Ingram Chair in Pediatric Oncology and deputy director of Vanderbilt-Ingram, serves as assistant director of the VERTICAL Program. Caroline Hartford is the senior program manager of VERTICAL.

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A new prospective clinical trial with updated data on COVID-19 hospitalizations and deaths among patients with cancer confirms the importance of vaccination and sheds light on which conditions put patients most at risk. 

Patients who had been vaccinated had a 50% reduction in risk of hospitalization, according to data from the National Cancer Institute COVID-19 in Cancer Patients Study (NCCAPS) published July 17 in JAMA Oncology.

Death incidence was highest in patients with lymphoma, intermediate in patients with acute leukemia and lung cancer, and lowest in patients with other solid tumors or with blood cancers other than lymphoma. Patients who had undergone chemotherapy or who had a history of stroke, atrial fibrillation and pulmonary embolism were at higher risk for hospitalization. 

The finding that patients with lymphoma had the highest risk of death suggests a potential detrimental effect of B-cell-depleting therapy on COVID-19 outcomes, the study stated, but the authors noted that this hypothesis was confounded by the inherent immunosuppression in patients with lymphoma. 

“These results are important because they represent the only prospective clinical trial in patients with a recent diagnosis of COVID and an active cancer undergoing therapy,” said the study’s lead author Brian Rini, MD, Ingram Professor of Cancer Research and Thomas F. Frist Sr. Professor of Medicine. 

Rini is one of two principal investigators of NCCAPS. The other is Lorissa Korde, MD, with NCI’s Cancer Therapy Evaluation Program, who is the study’s senior author. Patients were accrued for the study between 2020 and 2022, and the statistical analysis took place between September 2024 and April 2025. 

The study involved 1,572 adult patients who had a COVID-19 diagnosis within 14 days while receiving active treatment for cancer or had a prior stem cell transplant or CAR-T cellular treatment therapy. In addition to outcomes, investigators analyzed COVID-19 therapies patients received and disruptions in cancer treatment. The most common type of disruption was a delayed cancer treatment. 

The majority of patients had already been accrued for analysis before the Food and Drug Administration gave emergency use authorization for the antiviral treatment nirmatrelvir with ritonavir, which is most commonly known by its brand name, Paxlovid. Of the patients who enrolled in the study after the first COVID-19 vaccine received FDA emergency use authorization, 41.5% were fully vaccinated. 

“These data provide a road map to protect the most vulnerable cancer populations not only from COVID, but from potential future pandemics,” Rini said. 

Patients hospitalized for COVID-19 within 90 days of enrollment accounted for 18.4% of the study group. Among the hospitalized patients, 23.4% were admitted to an intensive care unit.  

The study was funded in part by the Coronavirus Aid, Relief, and Economic Security (CARES) Act, and also by the National Cancer Institute National Clinical Trials Network, Experimental Therapeutics Clinical Trials Network, and Community Oncology Research Program grants via the U10 funding mechanism.  

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Stand Up To Cancer (SU2C) has announced that its ninth biennial roadblock televised fundraising special will air on Friday, Aug. 15, from Nashville, bringing together country music stars, celebrities, athletes, cancer researchers and survivors for a powerful evening of inspiration and celebration.

This marks the first time the telecast will be broadcast from Nashville, and it will take place at The Pinnacle, a new premier event venue in the heart of Music City. Airing at 7 p.m. CT, the one-hour special continues SU2C’s 17-year mission to fund cancer research and save lives.

With the move to Nashville, SU2C will harness the city’s creative energy and musical heritage to bring a new dimension and excitement to this year’s show. The telecast will feature artists from country and other musical genres coming together in unique collaborations, an artistic reflection of SU2C’s commitment to scientific teamwork where researchers unite to accelerate progress.

Music icon Dolly Parton will appear in the special, with GRAMMY Award-winning artist Sheryl Crow serving as host. Additional performers and celebrity participants will be revealed in the weeks ahead.

Vanderbilt-Ingram Cancer Center is welcoming SU2C to Nashville.

“We are thrilled that Stand Up To Cancer will be bringing this special event to Nashville, and we welcome them to our city,” said Ben Ho Park, MD, PhD, Benjamin F. Byrd Jr. Professor of Oncology, professor of Medicine, and director of Vanderbilt-Ingram. “Our physicians, researchers and patients are familiar with the exceptional work of this organization that funds research to advance cancer treatments, which ultimately saves lives.

“This will be an extraordinary evening featuring some of Nashville’s most talented entertainers, and we hope everyone will join us for the telecast that will showcase not only our great city, but also the amazing research that has emanated from SU2C.”

As a leading academic medical center with deep roots in the region, Vanderbilt-Ingram shares SU2C’s commitment to advancing cancer research and improving patient outcomes.

“The goal of Stand Up To Cancer has always been about working collaboratively to push cancer research forward so we could help patients as quickly as possible,” said Katie Couric, SU2C co-founder. “Nearly two decades later, it’s incredibly gratifying and inspiring to see the impact of this research. Bringing the show to Nashville will infuse new energy and excitement into our mission. There’s still so much work to do and every dollar makes a difference — especially to the families who are counting on novel approaches and therapies as they face the challenges that often accompany a cancer diagnosis.”

The biennial special will be carried across more than 30 participating media platforms, including all four major U.S. broadcast networks, which are generously donating one hour of commercial-free primetime. Viewers will also be able to watch the telecast on-demand across multiple digital and streaming platforms, ensuring broad and flexible access to this one-night-only event.

Telecast viewers will hear from leading SU2C-funded researchers about recent advances and why continued support is vital in the fight against cancer. The program will also feature powerful stories from survivors who benefited from research made possible by donor contributions. From early detection to new treatment approaches, these stories reflect the real-world impact of SU2C-funded research and the hope it brings to patients and families.

Stand Up To Cancer was established in 2008 by a group of women who wanted to galvanize the entertainment community to raise awareness and funding to advance collaborative cancer research and end cancer as a leading cause of death.

Since its inception, SU2C has brought together over 3,100 top researchers from more than 210 leading institutions across 16 countries to collaborate on advancing cancer research.

SU2C-funded research has contributed to the saving of tens of thousands of lives worldwide.

To learn more about the 2025 event, visit https://standuptocancer.org. For more information visit StandUpToCancer.org, Instagram, TikTok, X, Facebook, and YouTube. 

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