A grant from VoLo Foundation will augment federal funding for the Southern Environmental Health Study, an initiative to determine whether environmental exposures are contributing to cancer cases in the region.

The study received its initial funding from the National Cancer Institute and the Vanderbilt-Ingram Cancer Center. A grant from VoLo Foundation — a private nonprofit organization dedicated to accelerating global impact through science-based solutions, education enhancement, and health improvement initiatives — will allow investigators to recruit additional participants and conduct methylation- and proteomics-based biological aging assays to check for biomarkers of early disease risk.

On cancer incidence and mortality maps, some of the highest rates in the country appear in the southern U.S., but whether environmental exposures are a contributing factor has not been scientifically determined. The study is a long-term cohort investigation that will follow participants for at least 10 to 20 years. The participants are between the ages of 40 and 70 and live in Alabama, Arkansas, Delaware, Florida, Georgia, Kentucky, Louisiana, Maryland, Mississippi, Missouri, North Carolina, Oklahoma, South Carolina, Texas, Tennessee, Virginia, West Virginia or the District of Columbia.

“Humans are exposed to large numbers of chemicals and their mixtures with more than 80,000 chemicals having been registered by the Environmental Protection Agency,” said Wei Zheng, MD, PhD, MPH, the Anne Potter Wilson Professor of Medicine and the director of the Vanderbilt Epidemiology Center. “However, very few of them have been adequately investigated in relation to human cancers and other diseases in epidemiologic studies. There are considerable challenges in studying environmental exposures in epidemiologic studies.”

Participants will wear silicone wristbands designed to collect chemicals, which researchers will use to measure exposure to approximately 500 compounds. They will also analyze blood samples to assess the internal exposome using both liquid chromatography and gas chromatography with high-resolution mass spectrometry, allowing them to detect approximately 1,500 confirmed chemicals and endogenous metabolites. To identify potential environmental carcinogens, the researchers will use an innovative exposome-wide association study to link chemical exposures with disease biomarkers, including indicators of biological aging and inflammation.

“Supporting the Southern Environmental Health Study aligns with our mission to advance data-driven solutions that can lead to healthier, more resilient communities. This research has the potential to uncover possible links between environmental exposures and chronic diseases,” said David Vogel, co-founder and chief scientist of VoLo Foundation.

Vogel and his wife, Thais Lopez Vogel, formed the VoLo Foundation in 2014.

“We are very grateful for the support of the VoLo Foundation and believe that this study will generate significant amounts of novel data regarding potential impacts of environmental exposures on human health and pave the way for future studies in this important area,” Zheng said.

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