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Research Advocacy

Since 2004, research advocates have been an integral part of the Breast SPORE team, offering patient experiences and perspectives into all aspects of breast cancer research at Vanderbilt-Ingram. These passionate, determined and dedicated volunteers are actively involved helping to bring the best science to those who are affected by breast cancer by contributing in the following ways:

Research Advocacy

Since 2003, research advocates have been an integral part of the GI SPORE team, offering patient experiences and perspectives into GI SPORE research at VICC. These committed cancer survivors and caregivers are actively involved helping to bring the best science to those who are affected by colorectal cancer by contributing in the following ways:

Developmental Research

The Developmental Research Program (DRP) supports pilot projects that allow early, high-risk research to move solid basic science findings toward clinical application, as well as the migration of provocative clinical observations back to the laboratory in order to understand their mechanistic basis.

Breast SPORE Research Projects

The SPORE in Breast Cancer supports four research projects aimed at addressing basic, clinical and population research questions of importance in human breast cancer. All projects are translational and multidisciplinary and are led by co-investigators from multiple departments across the School of Medicine, with complementary basic science and translational/clinical expertise.

Learn more about our Breast SPORE research projects and cores

Strategies to Improve Outcomes for Triple-Negative Breast Cancer Patients Integrating Subtype-Specific Genomic and Immune-Based Discoveries 

  • Clinical co-leader: Vandana G. Abramson, MD
  • Basic co-leader: Jennifer A. Pietenpol, PhD
  • Co-investigators: Brian Lehmann, PhD
  • Patient Advocates: Cat Dunham and Carolyn Pugh

Targeting Antigen Presentation to Improve Immunotherapy Responses in Breast Cancer 

  • Clinical co-leader: Laura Kennedy, MD, PhD
  • Basic co-leader: Justin M. Balko, PharmD, PhD
  • Co-investigator: Brent Ferrell, MD, Simon Mallal, MBBS, PhD, & Mary Philip, PhD
  • Patient advocate: Roberta Cassanova and Michelle Wyatt 

Liquid Biopsies to Guide Therapies in Triple-Negative Breast

  • Clinical co-leader: Vandana Abramson, MD
  • Basic co-leader: Ben Ho Park, MD, PhD
  • Co-investigators: Alexander Bick, MD, PhD
  • Patient Advocate: Edith McLeary and Laura Nasca

Overview

The Vanderbilt-Ingram Cancer Center SPORE in Breast Cancer has established a true multidisciplinary program focused on conducting multidisciplinary, mechanism-based, translational research of the highest possible impact that will contribute meaningfully to measurable progress in breast cancer. Our investigators have expertise in cellular signaling and molecular biology, breast pathology, medical, surgical, and radiation oncology, clinical trial design, epidemiology and population studies, mass spectrometry, biostatistics, and biomedical informatics.

The SPORE in Breast Cancer

Vanderbilt-Ingram Cancer Center's SPORE in Breast Cancer, established in 2003, is one of only six in the country, and focuses on innovative, translational research for better diagnosis, prognosis, screening, prevention and treatment of breast cancer.

Donor-Supported Research

A personal experience often is the catalyst for private gifts that will allow cancer scientists to do everything from prove the value of an untested idea to harvest tissue samples that will be stored and used for years in research studies.

Philanthropic giving often kick-starts the contributions of exceptional, early-career scientists and advances early ideas that are too “risky” to earn support from governmental sources.

Some donors attach very specific uses to the dollars while others give with the only restriction that cancer center put the funds where they will have the biggest impact. Vanderbilt-Ingram holds true to our donors’ wishes, and uses outside peer review to help prioritize the projects based on scientific merit.

In 2005, Jim and Janet Ayers gave $10 million to help Vanderbilt University scientists find early markers for colorectal cancer that could improve diagnosis and potentially save lives.

That gift established the Ayers Institute and has yielded an impressive return: identification of protein “signatures” of the genetic mutations that drive the nation’s second leading cancer killer after lung cancer.

 

When Waddell Walker Hancock founded the A.B. Hancock Jr. Memorial Laboratory for Cancer Research 40 years ago at Vanderbilt, she was determined that the right combination of imagination, perseverance and scientific talent could win the fight against cancer.

Hancock Lab researchers have earned many national honors and 13 patents for their studies of the role of the COX-2 enzyme in the progression of cancer and as a target for prevention and early detection.

The T.J. Martell Foundation became an important partner with the Vanderbilt-Ingram Cancer Center in 1993, when the Martell Foundation established the Frances Williams Preston Laboratories. These “laboratories without walls” were created in honor of Frances Preston, the late music industry icon and former president of the Martell Foundation's board and served as an important cornerstone in the creation of the then-new Vanderbilt Cancer Center.

The generous support from the Robert J. Kleberg, Jr. and Helen C. Kleberg Foundation has played a pivotal role in Vanderbilt-Ingram Cancer Center's ability to impact cancer discovery for nearly two decades.

Due to a long-term investment in basic and translational cancer science, support from the Robert J. Kleberg, Jr. and Helen C. Kleberg Foundation has enabled Vanderbilt to emerge as an international leader in the early detection of cancer and precision cancer medicine—matching the right therapy to the right patient at the right time.

Amy Baker was a media executive, entrepreneur, and advocate, whose famously open arms (and open door) made her home a nexus point connecting thought-leaders from across the worlds of media, politics and philanthropy. She was a dedicated supporter of breast cancer research at Vanderbilt University Medical Center, along with her family.

Other Ways To Give

If you wish to make a general gift to support the Ambassadors' mission, please choose one of these options:

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