Changes to the genome are at the epicenter of cancer mechanisms and response to therapies. The Genome Maintenance Research Program is a cohesive network of basic science researchers focused on understanding how DNA is damaged, repaired, packaged, expressed, and replicated.

Gastrointestinal (GI) cancers remain some of the most difficult to treat, with five-year survival rates below 50 percent for most GI cancer types.

The Gastrointestinal Cancer Research Program aims to better understand what drives these cancers with the goal of identifying and applying better treatment strategies. Our research efforts span the entire spectrum—from in-depth basic research to investigator-initiated clinical trials—across all GI cancer types, including colorectal, gastroesophageal, and pancreatic cancers.

The Cancer Health Outcomes and Control Program conducts research aimed at reducing the burden of cancer across the entire cancer care continuum. The research efforts of this interdisciplinary, collaborative program center on the themes of: 

The Cancer Epidemiology Research Program aims to improve our understanding of the genetic and environmental origins of cancer and to identify biomarkers for cancer risk and progression. This understanding informs the design of effective cancer prevention and control programs.

The Translational Research and Interventional Oncology Research Program  is an integrated multi-disciplinary program that provides the opportunity for clinical investigators and laboratory scientists to collaboratively address the rapidly changing landscape of cancer therapy. The program traverses multiple disciplines, including precision oncology, immuno-oncology, cellular therapy, and immune-toxicity.