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Lung cancer metastasis-National Cancer Institute \ Winship Cancer Institute of Emory University

Host-Tumor Interactions Research Program

Tumor growth, invasion, and metastasis depend not only on the tumor cell alone, but also on the complex interactions between the cancer, stromal, and immune cells. The goal of the Host-Tumor Interactions Research Program is to develop a detailed and mechanistic understanding of the complex cell and microenvironment in which cancer cell interact, and how these interactions influence cancer therapies and immunotherapies.

RESEARCH THEMES

With the goal of understanding how complex interactions between tumor cells and their host contribute to cancer, the Host-Tumor Interactions program focuses on three specific research themes:

Uncovering basic immune regulatory mechanisms in anti-tumor immunity and how inflammation can be exploited to eliminate cancer or can trigger and promote tumors

Establishing single cell biology and modeling approaches to assess the composition and roles of the heterogeneous cell populations in tumor progression or therapeutic responses.

Integrating and developing molecular imaging technologies to understand and monitor how tumors evolve in a changing microenvironment

Meet the Program Members

The Host-Tumor Interactions program is co-led by Mary M. Zutter, M.D., and Jeffrey Rathmell, Ph.D. The basic, translational, and clinical scientists who make up this program are focused on discovering and understanding these interactions, with the ultimate goal of developing strategies to control tumor progression and metastasis by targeting these interactions.


Featured Publications

Program News

November 12, 2020

New therapeutic target for lung cancer

Continuous activation of cell surface receptors increases signaling that can promote oncogenic transformation. One receptor, EphA2, has been identified as a driver of lung cancer, but its interacting partners are not well characterized.
December 13, 2019

Richmond receives legacy award from Society for Leukocyte Biology

Ann Richmond, PhD, Ingram Professor of Cancer Research, is the 2019 recipient of the Society for Leukocyte Biology Legacy Award.
November 7, 2019

Project seeks new way to assess immunotherapy effectiveness

GE Healthcare has awarded researchers $2.5 million in funding to develop PET tracer that will determine the effectiveness of immunotherapy in patients early in their treatment course.