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Study finds a role for AI in drug repurposing pipeline

Submitted by robbikm2 on

A research team led by Wei-Qi Wei, MD, PhD, reported their findings on February 26th in Nature Digital Medicine. Their study searched for new treatments for Alzheimer’s disease (AD) by asking ChatGPT whether any existing drugs used for other problems might help patients with AD. ChatGPT is a cloud-based artificial intelligence program, a so-called large language model that’s been optimized for chat.

This study will have two Phases: Phase 1a and Phase 1b. The goal of Phase 1a of this clinical study is to learn more about the safety, tolerability and dosing of study drug KITE-197, in participants with relapsed or refractory large B-cell lymphoma (r/rLBCL). The goal of Phase 1b of this clinical study is learn about the effectiveness of the recommended dose of KITE-197 in participants with r/r LBCL. The primary objectives of this study are: Phase 1a: To evaluate the safety of KITE-197 in participants with r/r LBCL and determine the target dose level for Phase 1b. Phase 1b: To evaluate the efficacy of KITE-197 in participants with r/r LBCL as measured by the complete remission (CR) rate.

Jonathan Brunger, Ph.D., M.S.

  • Assistant Professor of Biomedical Engineering

Jonathan Brunger, Ph.D., M.S.

  • Assistant Professor of Biomedical Engineering

jonathan.m.brunger@Vanderbilt.Edu

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