Vanderbilt-Ingram Cancer Center

Levels of Evidence for Cancer Genetics Studies (PDQ®)–Health Professional Version

Introduction

[Note: Many of the medical and scientific terms used in this summary are found in the

Genetics of Renal Cell Carcinoma (PDQ®)–Health Professional Version

Inheritance and Risk of Renal Cell Carcinoma

Michael Topf, MD

Associate Professor of Otolaryngology

Michael Topf, MD

Associate Professor of Otolaryngology

michael.topf@vumc.org

Alexander Bick, Ph.D., M.D.

Associate Professor of Medicine
Director, Division of Genetic Medicine
Edward Clairborne Stahlman Chair #3

Alexander Bick, Ph.D., M.D.

Associate Professor of Medicine
Director, Division of Genetic Medicine
Edward Clairborne Stahlman Chair #3

alexander.bick@vumc.org

Cristina Kline-Quiroz, D.O.

Assistant Professor of Physical Medicine and Rehabilitation

Cristina Kline-Quiroz, D.O.

Assistant Professor of Physical Medicine and Rehabilitation

cristina.kline-quiroz@vumc.org

Venkataswarup Tiriveedhi, MD, PhD

Associate Professor
Director, Human Anatomy and Physiology
Director, Tumor Immunology Laboratory
Adjunct Professor, Vanderbilt University

Contact

Phone

615-963-5779

venkataswarup.tiriveedhi@vanderbilt.edu

3500 John A Merritt Blvd
Nashville, TN 37209

Venkataswarup Tiriveedhi, MD, PhD

Associate Professor
Director, Human Anatomy and Physiology
Director, Tumor Immunology Laboratory
Adjunct Professor, Vanderbilt University

615-963-5779

venkataswarup.tiriveedhi@vanderbilt.edu

3500 John A Merritt Blvd
Nashville, TN 37209

Comparing Sentinel Lymph Node (SLN) Biopsy With Standard Neck Dissection for Patients With Early-Stage Oral Cavity Cancer

Read more about Comparing Sentinel Lymph Node (SLN) Biopsy With Standard Neck Dissection for Patients With Early-Stage Oral Cavity Cancer

This phase II/III trial studies how well sentinel lymph node biopsy works and compares sentinel lymph node biopsy surgery to standard neck dissection as part of the treatment for early-stage oral cavity cancer. Sentinel lymph node biopsy surgery is a procedure that removes a smaller number of lymph nodes from your neck because it uses an imaging agent to see which lymph nodes are most likely to have cancer. Standard neck dissection, such as elective neck dissection, removes many of the lymph nodes in your neck. Using sentinel lymph node biopsy surgery may work better in treating patients with early-stage oral cavity cancer compared to standard elective neck dissection.

Cosmas Okoro, PhD

Professor of Organic Chemistry

Contact

Phone

615-963-5332

cokoro@tnstate.edu

Department of Chemistry, Tennessee State University
3500 John A. Merritt Blvd.
Nashville, TN 37209-1561

Cosmas Okoro, PhD

Professor of Organic Chemistry

615-963-5332

cokoro@tnstate.edu

Department of Chemistry, Tennessee State University
3500 John A. Merritt Blvd.
Nashville, TN 37209-1561

Research

Research Program

Profile

A Study to Compare Blinatumomab Alone to Blinatumomab With Nivolumab in Patients Diagnosed With First Relapse B-Cell Acute Lymphoblastic Leukemia (B-ALL)

Read more about A Study to Compare Blinatumomab Alone to Blinatumomab With Nivolumab in Patients Diagnosed With First Relapse B-Cell Acute Lymphoblastic Leukemia (B-ALL)

This phase II trial studies the effect of nivolumab in combination with blinatumomab compared to blinatumomab alone in treating patients with B-cell acute lymphoblastic leukemia (B-ALL) that has come back (relapsed). Down syndrome patients with relapsed B-ALL are included in this study. Blinatumomab is an antibody, which is a protein that identifies and targets specific molecules in the body. Blinatumomab searches for and attaches itself to the cancer cell. Once attached, an immune response occurs which may kill the cancer cell. Nivolumab is a medicine that may boost a patient's immune system. Giving nivolumab in combination with blinatumomab may cause the cancer to stop growing for a period of time, and for some patients, it may lessen the symptoms, such as pain, that are caused by the cancer.