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Smita Misra, PhD

  • Assistant Professor

Smita Misra, PhD

  • Assistant Professor

smisra@mmc.edu

Research Program

Have any questions? Contact Us 1-877-936-8422 for more information
This phase II trial studies the best approach to combine chemotherapy and radiation therapy (RT) based on the patients response to induction chemotherapy in patients with non-germinomatous germ cell tumors (NGGCT) that have not spread to other parts of the brain or body (localized). This study has 2 goals: 1) optimizing radiation for patients who respond well to induction chemotherapy to diminish spinal cord relapses, 2) utilizing higher dose chemotherapy followed by conventional RT in patients who did not respond to induction chemotherapy. Chemotherapy drugs, such as carboplatin, etoposide, ifosfamide, and thiotepa, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Radiation therapy uses high energy x-rays or high-energy protons to kill tumor cells and shrink tumors. Studies have shown that patients with newly-diagnosed localized NGGCT, whose disease responds well to chemotherapy before receiving radiation therapy, are more likely to be free of the disease for a longer time than are patients for whom the chemotherapy does not efficiently eliminate or reduce the size of the tumor. The purpose of this study is to see how well the tumors respond to induction chemotherapy to decide what treatment to give next. Some patients will be given RT to the spine and a portion of the brain. Others will be given high dose chemotherapy and a stem cell transplant before RT to the whole brain and spine. Giving treatment based on the response to induction chemotherapy may lower the side effects of radiation in some patients and adjust the therapy to a more efficient one for other patients with localized NGGCT.

Featured Speakers:

Denise Aberle, MD

(UCLA Jonsson Comprehensive Cancer Center)

is a professor of Radiology in the School of Medicine and professor of Bioengineering in the Henry Samueli School of Engineering and Applied Sciences. She is board-certified in Internal Medicine and Diagnostic Radiology. Dr. Aberle's research centers on lung cancer screening, early diagnosis, prevention, and screening implementation. Other interests include oncologic imaging for response assessment; quantitative image analysis, and oncology informatics.

M. Patricia Rivera, MD, ATSF, FCCP

(URMC Wilmot Cancer Center)

is the C. Jane Davis & C. Robert Davis Distinguished Professor in Pulmonary Medicine, Chief of the Division of Pulmonary Diseases and Critical Care Medicine at the University of Rochester Medical Center (URMC). Dr. Rivera specializes in lung cancer screening, diagnosis, staging, and management of treatment complications.

Julien Sage, PhD

(Stanford Cancer Institute)

is the Elaine and John Chambers Professor in Pediatric Cancer and a Professor of Genetics at Stanford University where he serves as the co-Director of the Cancer Biology PhD program. Dr. Sage became initially interested in small cell lung cancer because of the nearly ubiquitous loss of RB in this cancer type and the intriguing relationship in mice and humans between loss of RB and the growth of neuroendocrine lesions. In the past few years, the Sage lab has developed pre-clinical models for small cell lung cancer and has used these models to investigate signaling pathways driving the growth of this cancer type and to identify novel therapeutic targets in this recalcitrant cancer.

Sudhir Srivastava, PhD, MPH

(National Cancer Institute)

is the Chief of the Cancer Biomarkers Research Group at the National Cancer Institute. His efforts focus on molecular biology of malignancies, early malignancies, risk assessment, and informatics, providing leadership in the areas of molecular screening and early detection. He is one of the principal authors of the Bethesda Guidelines for diagnosing Hereditary non-polyposis colorectal cancer.

Advances in Lung Cancer Research

Deonni Stolldorf, Ph.D.

  • Associate Professor of Nursing

Deonni Stolldorf, Ph.D.

  • Associate Professor of Nursing

615-343-0637

deonni.stolldorf@vanderbilt.edu

Research Program

Have any questions? Contact Us 1-877-936-8422 for more information
This phase I/II trial studies the side effects and best dose of a combination of gabapentin and ketamine and to see how well it works to prevent acute and chronic pain in patients receiving chemotherapy and radiation therapy (chemoradiation) for head and neck cancer that has spread to nearby tissue or lymph nodes (locally advanced). Gabapentin is a medication that is commonly used to treat nerve related pain. Specifically, it has been used to treat pain involving the mouth, throat and nasal passages in head and neck cancer patients treated with radiation. Ketamine is a type of general anesthetic that blocks pathways to the brain involved with sensing pain. This trial may help doctors determine how patients tolerate the combination of gabapentin and ketamine and to find the correct dosing for ketamine in those taking gabapentin. This will be the basis for a future, larger study to look at how effective this combination is at reducing and/or preventing pain in head and neck cancer patients.

Danxia Yu, Ph.D.

  • Associate Professor of Medicine (Epidemiology)

Danxia Yu, Ph.D.

  • Associate Professor of Medicine (Epidemiology)

615-936-7389

danxia.yu@vumc.org

Research Program

Research Description

Have any questions? Contact Us 1-877-936-8422 for more information

Christine Smith, M.D.

  • Assistant Professor

Christine Smith, M.D.

  • Assistant Professor

christine.m.smith.2@vumc.org

Research Program

Research Description

Have any questions? Contact Us 1-877-936-8422 for more information
This phase III trial investigates the best dose of vinblastine in combination with selumetinib and the benefit of adding vinblastine to selumetinib compared to selumetinib alone in treating children and young adults with low-grade glioma (a common type of brain cancer) that has come back after prior treatment (recurrent) or does not respond to therapy (progressive). Selumetinib is a drug that works by blocking a protein that lets tumor cells grow without stopping. Vinblastine blocks cell growth by stopping cell division and may kill cancer cells. Giving selumetinib in combination with vinblastine may work better than selumetinib alone in treating recurrent or progressive low-grade glioma.
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